Program of the 13th ESLHO Symposium

Multi-omics approaches for diagnosis and monitoring of hematological malignancies

08:00 – 09:00

Registration

09:00 – 09:05

Welcome

08:30 – 12:00

Session 1: Technical strategies and platforms

Single-cell omics in chronic lymphocytic leukemia: an interim report on stereotyped subsets - Richard Rosenquist, Stockholm, SE
Spatial transcriptomics analyses of germinal center-derived B cell lymphomas - Pierre Milpied, Marseille, FR
Can Nanopore sequencing be applied to TCR libraries generated using two-step EuroClonality-NGS primer sets? - Christine Jones, London, UK

10:30 – 11:00

Coffee break

11:00 – 12:00

Poster blitz presentations

12:00 – 14:00

Lunch and Poster session

14:00 – 15:30

Session 2: Application of multi-omics in hematological malignancies

Large T cell clones expressing immune checkpoints increase during multiple myeloma evolution and predict treatment resistance - Bruno Paiva, Pamplona, ES
Insights into intra-tumour heterogeneity and transformation in follicular lymphoma through multi-omics - Jessica Okosun, London, UK
Transcriptome sequencing for precision diagnostics in ALL - does it make a difference? - Lorenz Bastian, Kiel, DE
Exploring the cell-free genome and transcriptome as biomarker sources in IgM gammopathies - Philippe Decruyenaere, Ghent, BE
Navigating switching acute lymphoblastic leukemia through proteogenomics and trajectory inference - Vojen Sadilek, Prague, CZ

15:30 – 17:00

Session 3: Integration of omics

LymphoID: development of an integrated approach combining EuroFlow and EuroClonality-NGS validated assays for the diagnosis of lymphoproliferative disorders - Peter Stewart, Belfast, UK
Combined targeted proteomics, immunomics, and genetics for early detection of lymphoma - Martijn Kolijn, Rotterdam/Utrecht, NL

17:00 – 17:30

Coffee break

17:30 – 19:00

Session 4: Open abstract session on innovative laboratory diagnostics in hemato-oncology and immunology

EuroClonality-NGS amplicon assay reveals age-dependent IG/TR maturation profiles in acute lymphoblastic leukemia - Monika Brüggemann on behalf of Michaela Kotrová, Kiel DE
Integration of omics reveal how acute graft versus host disease does not affect the composition of T cell compartment but impacts on T cell expression pattern - Marco Sindoni, Milan, IT
PIDgeon: an explainable AI model for improved flow cytometry-based screening of lymphoid primary immunodeficiencies - Annelies Emmaneel, Ghent, BE
UMA panel: an NGS approach to define the molecular profile of MM patients. Results of intra- and inter-laboratory validation experiments - Barbara Taurisano, Bologna, IT
New flow assay for molecular detection of p.D816V KIT mutation in mast cell activation syndromes - Paula Navarro, Salamanca, ES

18:45 - 19.00

Poster prize and closing remarks

19:00 – 23:00

Drinks & Symposium dinner